The rapid growth of new AI systems like ChatGPT and Google Gemini has helped us recognize that profound change is on the horizon. Although many of us still think of these capabilities as little more than improved internet search tools, the implications are far deeper. Like the agricultural, industrial, and computer revolutions before it, the AI revolution will transform nearly every aspect of how we live and work, including our economies, our healthcare, the food we eat, and our interactions with the world around us. In this visionary, far-reaching, and highly practical talk, leading futurist and bestselling author of Superconvergence, Hacking Darwin, and The AI Ten Commandments, Jamie Metzl explores the big-picture implications of this transformative moment in history when we are rapidly increasing our ability to engineer intelligence and re-engineer biology—and shows how individuals, organizations, and societies can ride this wave of change rather than be overwhelmed by it.

For centuries, healthcare has been reactive. We waited for people to get sick, then tried—often heroically—to save them. That era is now ending. Medicine is already shifting from one-size-fits-all treatment to precision healthcare shaped by each person’s unique biology. Genome sequencing, targeted cancer therapies, and data-driven diagnostics are already delivering extraordinary results. But as generative AI and exponential computing power converge with genomics, biotechnology, and vast health datasets, medicine is moving beyond precision toward predictive and preventive care models in which we can anticipate risk, intervene early, and keep people well before symptoms appear. In this fast-paced, visionary, and deeply practical keynote, technology and healthcare futurist Jamie Metzl, Commissioner of the Lancet Commission on Precision Health, takes audiences inside the next healthcare revolution and shows how AI and other new capabilities are transforming disease detection, drug development, care delivery, and health economics, and what it will take for leaders to thrive as prediction, prevention, and personalization redefine healthcare success.

Whether we’re ready or not, artificial intelligence is set to transform nearly every dimension of human life, including how we work, live, create art, find meaning, and build communities of belief. Just as agriculture reshaped human civilization and seeded new faith traditions and the printing press fractured old authorities while giving rise to new ones, AI is now triggering the next great shift in how we understand ourselves and our place in the unfolding human story. In this mind-opening journey through deep history and near-future possibility, leading futurist, sci-fi novelist, and author of The AI Ten Commandments Jamie Metzl explores what happens—and how we can thrive—when our most powerful technologies begin to touch the most human questions: Who are we? What do we owe one another? And what does it mean to create, to believe, and to belong in an age of highly creative, and potentially even spiritual, machines? This keynote helps leaders, creators, and organizations understand not just what AI can do, but how we can strengthen human meaning, creativity, and values as intelligent machines increasingly shape our lives and societies.

Most people know the basics of healthy longevity: exercise, good nutrition, meaningful relationships, and stress reduction. But revolutionary advances in biology, genetics, and artificial intelligence are now creating unprecedented opportunities to extend healthy human life beyond what was once considered possible, and unlocking new potential for health, productivity, and human flourishing in ways our ancestors could never have imagined. In this eye-opening and highly practical keynote, leading technology and healthcare futurist (and ultramarathoner) Jamie Metzl explores the latest breakthroughs in longevity science and what they mean for individuals, businesses, and governments. He explains how these advances could deliver more of life’s most precious resource—time—and why they will fundamentally reshape healthcare systems, economies, social structures, and public policy sooner than most people expect. This talk offers a clear framework for how leaders can prepare now for a future in which longer, healthier lives transform how we live and work, and even how our societies are organized.

While many people feel overwhelmed by a flood of unscientific health claims and exaggerated promises about “hacking” aging or living forever, the converging revolutions in artificial intelligence, genetics, and biotechnology are delivering something far more powerful: real scientific insights into prevention, prediction, and long-term health with meaningful implications for every one of us. In this affirming, optimistic, and highly practical keynote, leading technology and healthcare futurist Jamie Metzl—who has completed 60 marathons, 40 ultramarathons, and 13 Ironman triathlons—explores how individuals can use today’s best science, not hype, to optimize their health and position themselves to benefit from the next generation of predictive and preventive medicine. This talk offers a clear, empowering framework for living healthier, more resilient lives in a world of rapidly accelerating technological change.